From Little Rock, AR follow Interstate 40 east to the Brinkley exit. Follow Highway 49 south into West Helena. At the first stoplight, take a right, continuing on 49 south through three stoplights. At the four-way stop sign, go straight and take the second right (Phillips Street). Follow Phillips Street to its end; take a right on Cherry Street. The Delta Cultural Center Visitors Center is immediately on your right, the Cherry Street Pavilion is on your left and the Delta Cultural Center Depot is one block south on the left.
From Clarksdale, MS or Memphis,TN follow Highway 49 north from Highway 61. After crossing the Mississippi River bridge, take a right on to Highway 49B. At the four-way stop sign, go straight and take the second right (Phillips Street). Follow Phillips Street to its end; take a right on Cherry Street. The Delta Cultural Center Visitors Center is immediately on your right, the Cherry Street Pavilion is on your left and the Delta Cultural Center Depot is one block south on the left.